Abatacept (Orencia)

Abatacept is a medication that helps patients with inflammation. Inflammation can make joints-like the knee, elbows, wrists, and/or fingers hurt or swell. Abatacept works by blocking the signals in the body that cause inflammation. Abatacept can help people feel better and move their joints more easily because it prevents inflammation. It is often given as an IV infusion (which is like a small straw that nurses put in your arm to help deliver medication) or an injection into the skin.

What are the possible side effects?

Most of the side effects of this medication are uncommon or mild. The most common side effects are nausea, headaches, common colds, and sore throats. It is possible to be allergic to this medication.

What else should I know if my child is taking Abatacept?

It is important to talk to your healthcare provider before getting any vaccines. If possible, your child may need to get vaccines before starting Abatacept. 

Should my child take Abatacept if they are not feeling well?

Abatacept can make it harder for your child to fight off infections. If your child is sick, taking antibiotics, has a fever (temperature of 100.4 °F [38 °C] or greater) or if you are unsure if your child should take Abatacept, please call your child’s healthcare team to discuss at 212-263-9969.

Where can I read more about Abatacept?

You can learn more about this medicine through the QR code below, which takes you to the American College of Rheumatology (ACR).

If you have any questions, please message us on MyChart, or call the care team at 212-263-9969.

Created in partnership with families and expertise from our Sala Institute for Child and Family Centered Care.

©2025 NYU Langone Health. All rights reserved. Reviewed for health literacy. This information is not intended as a substitute for professional medical care. Always follow your health care provider's instructions.